Gloria Fallon, the mother of The Tonight Show host Jimmy Fallon, passed away this weekend in hospital at the age of 68.
The Tonight Show will not air for the week of November 6-10, and repeat episodes will fill the time slot.
"On behalf of everyone at NBC, we extend our deepest condolences to Jimmy and all his family at this time of enormous loss. Our hearts go out to Jimmy and everyone else whose lives were so touched by Gloria Fallon's love, kindness and support," the network told the outlet in a statement.
This sad new comes after Fallon cancelled Friday's taping of The Tonight Show Starring Jimmy Fallon because of a "private Fallon family matter."
The 43-year-old talk show host, went to visit his mother, Gloria, when she was sick in hospital.
"Jimmy Fallon's mother, Gloria, died peacefully on Saturday," A Fallon family spokesperson told PEOPLE in a statement. "Jimmy was at his mother's bedside, along with her loved ones, when she passed away at NYU Langone Medical Center in NYC. Our prayers go out to Jimmy and his family as they go through this tough time."
Fallon told PEOPLE in a statement, "Today I lost my biggest fan."
"Jimmy comes from a very close knit family, and together with the rest of his loved ones they are by her side right now," the source added.
Since the news broke, fans and friends have taken to social media to express their condolences for the comedian.
"Heartbroken for your loss," wrote Brooklyn Nine-Nine star Terry Crews.
Heartbroken for your loss @jimmyfallon. 💔
— terrycrews (@terrycrews) November 5, 2017
"So very sad to hear about @jimmyfallon's mum, Gloria," wrote Terri Irwin, who lost her husband Steve Irwin over a decade ago. "She must have been a beautiful soul because her son has such a kind and loving heart."
So very sad to hear about @jimmyfallon's mum, Gloria. She must have been a beautiful soul because her son has such a kind and loving heart.
— Terri Irwin (@TerriIrwin) November 5, 2017
"I'm sad to say my friend Jimmy's mother has passed away... sending him all the love in my heart ... Keep smilin Jimmy....." Miley Cyrus tweeted.
I'm sad to say my friend Jimmy's mother has passed away... sending him all the love in my heart ... Keep smilin Jimmy..... pic.twitter.com/SWaAA4YjRn
— Miley Ray Cyrus (@MileyCyrus) November 6, 2017
"l know it's tough to do when we lose someone we care about, I couldn't (imagine) not havin my mama," she added in a second tweet. "I am so sorry."
l know it's tough to do when we lose someone we care about , I couldnt image not havin my mama.... I am so sorry .... https://t.co/2WSdQJgjcu
— Miley Ray Cyrus (@MileyCyrus) November 6, 2017
"Jimmy's mom was full of energy, fun, a hearty laugh & twinkle in her eye. The apple didn't fall far from the tree. Love to all the Fallons," tweeted Andy Cohen.
Jimmy's mom was full of energy, fun, a hearty laugh & twinkle in her eye. The apple didn't fall far from the tree. Love to all the Fallons
— Andy Cohen (@Andy) November 5, 2017
Gloria Fallon also attended the taping of her son's first night hosting The Tonight Show in 2014.
"Mom is the first audience and the best. Remembering Jimmy Fallon and his family in our prayers today," wrote "The Late Show" host Stephen Colbert, who lost his mother in 2013 while hosting his own show on Comedy Central.
Mom is the first audience and the best. Remembering Jimmy Fallon and his family in our prayers today.
— Stephen Colbert (@StephenAtHome) November 5, 2017
While Jimmy usually keeps his family life out of the spotlight, he has shared funny stories and sweet moments about his mom.
Fallon describes his childhood with his mom Gloria, dad Jim and sister Gloria in a 2004 article with New York magazine.
"My dad was in Vietnam, and he was in a doo-wop group," Fallon said. "My mom was like a total square; she wasn't allowed to leave her stoop in Brooklyn. She was a nun for about a month, but then she was like, "˜You know what? I didn't get the calling!' Ha!"
In June, he told Howard Stern that his mother used to be a nun.
He also revealed that his parents grew up together in Brooklyn and met in high school.
A month before, he shared a memory of Gloria as part of his #MomQuotes segment of the talk show.
"My mom and I were talking on the phone for the third time that day and she actually said, "˜We don't talk enough,' " he tweeted.